Autism Part 1

Autism Part 1 Part 2

THE AUTISTIC SPECTRUM DISORDERS (ASD) PART 1

The autistic spectrum disorders (ASD) is a neurodevelopmental disorder characterized by social aloof behavior and impairment of language and social interactions. Advanced functional brain imaging has confirmed pervasive neurological involvement.

Often accompanied by seizure disorder, cognitive defects, or other neurological impairment manifests in the first three years of life and persists into adulthood if not treated.

I believe the etiology results initially from mercury toxicity which is transmitted transplacentally through the mother’s placenta to the baby and from subsequent vaccinations containing mercury.

Autistic children additionally have abnormalities of detoxification, specifically sulfoxidation and liver detoxification as well as glutathione.

THE AUTISTIC SPECTRUM DISORDERS (ASD) PART 1

Both of these abnormalities contribute to the high burden of xenobiotics frequently found in these patients. Frequent copper-zinc imbalances implies metallothionein impairment that could further impact negatively on sulfur metabolism and detoxification and intestinal lining integrity.

Intestinal hyperpermeability manifests in autistic children as dysbiosis, food intolerance, and exomorphin (opioid) intoxification most frequently from casein and gluten. Immune system abnormalities encompass derangements of antibody production, aberrant cytochromic profiles and other impairments consistent with chronic inflammation or immunity. There are also coagulation abnormalities reported.

I believe that autoimmunity, inflammation, toxins, metals, infections are the cause.

INTRODUCTION

In 1943, psychologist, Leo Kanner, published case histories of a childhood developmental disorder he called autism.

Autistic children seemed abnormally withdrawn, almost self-occupied, and out of touch with reality. As a group, they scored significantly lower on measured adaptive and life skills than the general population. Individuals with autism tend to have extreme difficulty learning from experience and modifying their behavior to accommodate varying situations.

Coping with the unpredictability of the social world is extremely demanding, even overwhelming, and anxiety exacerbates the problem.

Adults exhibit rage or complete dependence. Most are able to benefit from structured training programs with marked improvement in the quality of life.

Autism has become an epidemic in industrial societies. In the United States, autism was relatively rare until 1990 after which its prevalence increased by at least double and more likely three to five times. Similar steep increases in prevalence have been recorded in the United Kingdom as well as South Africa and China. The gender ratio is 3-4:1 boys to girls.

WHEN DOES IT START?

Autism begins very early in life. Almost all autistic patients are normal in physical appearance, but physiologic abnormalities become evident within mere months of birth. There may be sensory and motor dysfunction, cognitive or mental processing defects.

In the majority of cases, it starts to become apparent as the parent notices the growing child is not using words to communicate even though the child can usually recite the alphabet. In some cases, the child has developmental regression. Parents report their child was developing normally and then regressed, occasionally abruptly in language, sociability and play. In rare cases, motor skills also regress. After a plateau that lasts for some months, developmental resumes, but in most cases never returns to previous levels.

Some autistic children make little progress throughout their life, remaining nonverbal and severely withdrawn or mentally deficient while others fare better, although complete recovery is rare; however, I have seen miraculous recovery in some of the modalities that I will mention in these writings. While 75% of cases are mentally retarded, only 50% of those with autism cases exhibit retardation. As many as 1 in 10 are savants, gifted in areas such as music, drawing, memorization or calculation.

The conceptual interrelationship of the autistic spectrum disorder includes autism, Rett’s disorder, Asperger’s disorder, childhood disintegrative disorder, and atypical autism not otherwise specified.

Unfortunately, persons with autism may have a reduced life expectancy, and those with the most severe mental retardation tend to die soonest. Death due to seizure disorders are 24 times that of background.

COMORBID CONDITIONS:

There has been an association between autism and seizure disorder, and seizure disorder may occur in up to 30% of individuals with autism. Also, autistic people have other medical conditions including sensory impairment such as blindness, deafness, and neurofibromatosis.

THE RISING PREVALENCE OF AUTISM :

Surveys conducted prior to 1990 showed nationwide prevalence in the United States was estimated at about 5 per 10,000 for autism disorder. By 1997, the prevalence of autistic spectrum disorder was estimated to be 50 per 10,000. The following factors have been involved with increasing autism rates: mercury exposure by injections in infancy, antibiotic use, increase in combined live viral vaccines, and a number of vaccinations. There is also increased soil depletion leading to vitamin and mineral deficiencies as well as decreased omega-3 and omega-6 essential fatty acids in diet, and of course there is greater exposure to xenobiotic toxins. From 1987 to 1998, the number of children being treated for autism in California jumped 273%. A nationwide figure for 1991 to 1997 was 556%. I feel that the causes are mercury infections and EMS.

THE BRAIN IS ON FIRE

There have been several hypotheses concerning cerebral dysfunction including problem solving, mental operation, memory, shifting attention, and inhibition of inappropriate responses.

The most recent feeling is that there is an autoimmune cascade of events secondary to mercury and that mercury is a direct neurotoxin to the brain cell.

By PET imaging and functional MRIs, SPECT scanning of the brain has found that autistic children manifest abnormally low blood flow in the temporal areas and abnormalities throughout the brain including the frontal lobe. Old PET studies are consistent with disorganized establishment of normal circuits in the frontal as well as temporal area. The amygdala and hippocampus are also involved. There are dysfunctional connections between the temporal lobe and frontoparietal lobes and abnormality to the limbic system which explain the emotional abnormalities and the auditory regions and sensory perception abnormalities.

GENETIC PREDISPOSITION

A solid body of evidence indicates genetics play a role in autism, probably not as an inborn error but as a strongly predisposing factor. There is evidence for very high multi-genetically determined heritability as evidenced by the 50% concordance rate for monozygotic twins versus about 3% for dizygotic twins.

A small proportion of autistic individuals, not more than 10-15%, demonstrate comorbidity with no genetic conditions including tuberous sclerosis, neurofibromatosis, and fragile X syndrome. In addition, Rett’s disorder shows chromosomal abnormalities.

DETOXIFICATION IMPAIRMENTS

There are sulfoxidation abnormalities seen in autistic children. This is seen in approximately 32.5% and they are represented as poor metabolizers; 2.5% are nonmetabolizers of sulfoxidation. Of note, inorganic sulfate is important for many physiologic functions, and the liver relies on its sulfate pool to neutralize phenolic substances that are common in foods and contaminants. Interestingly, dopamine, epinephrine, and Tylenol are all metabolized through this pathway.

Abnormalities in methylation and other pathways including glutathione are seen.

In addition to the liver relying on filtration, the gastrointestinal tract also relies on it for its essential functions to help detoxify and keep the mucosa healthy. Unfortunately, the xenobiotic overload with contaminants such as xylenes, toluene, benzene, styrene, and others are found.

These alterations in filtration affect not only neurotransmitter systems but integrity of the gut lining and lead to a heightened vulnerability to food-borne or pollutant xenobiotic overload. There is found to be increased cysteine which is a known excitatory amino acid, and in that proportion of the population who cannot really transform it to sulfate, there might be a real problem.

EXCESSIVE ACCUMULATION OF XENOBIOTIC POLLUTANTS

Autistic children are toxic.

Blood analysis for several specific xenotoxins are common in autistic children.

The environment is polluted. Pesticide spraying is still routine in many school districts. Heavy metals, herbicides, fungicides, organic solvents have been linked to abnormalities of behavior, perception and cognition. Chronic exposed children to aluminum, cadmium, mercury, and lead often lead to developmental abnormalities. The typical moderate home is not a clean protected area. It is imbedded with dust, mold, germs, and radon contamination. Please be aware that children are especially vulnerable due to the immature detoxification system.

RECENT STUDIES SHOW IT MAY BE LYME DISEASE

I use various tick specific labs .

STOOL ANALYSIS, DIGESTIVE FUNCTION ABNORMALITIES : CANDIDA and OTHERS

Pathogenic organisms such as parasites, mold, virus should be tested for and eliminated.

Tartaric acid is a potentially harmful approved food additive and can appear in the urine of autistic kids at very high levels.

Elevated urine arabinose has also been linked with yeast overdose seen in Candida species. These are sometimes seen higher in autistic children.

INTESTINAL LINING ABNORMALITIES, LEAKY GUT:

These children have impairments of digestion, absorption or barrier functions. The mucosal barrier cells are not able to be repaired due to metabolic filtration defects.

IMPAIRED GLUTATHIONE

There are abnormalities in glutathione seen in the mothers and children by age 8 to be discussed later in section 2. It is thought that defects in methylation are also involved after vaccines are administered to that genetically susceptible person.

IMMUNE SYSTEM DYSFUNCTION :

MEASURE AUTOANTIBODIES,
GLUTEN,
CYTOKINES

Cell mediated immunity is often abnormal in autism. Abnormalities of macrophages, B cells, T cells and natural killer cells have been reported. Killer cells are decreased in approximately 40% of these children, and CD4 T cells are also decreased in approximately 35%. There have also been other abnormalities noted of the immunoglobulin system, and inflammatory cytokines are raised.

IMBALANCES OF TH1, TH2, t reg and t 17 are seen

COAGULATION ABNORMALITIES

There has been recent attention to increased activation of the clotting system with increased prothrombin-thrombin complexes as well as fibrinogen and fibrin in these patients.

MERCURY

Autistic children have impaired capacity to detoxify mercury.

This is seen in 100% of autistic children with impaired liver detoxification. Many also have poor metallothionein status therefore lowering their capacity to neutralize mercury and other heavy metals. Of course, mercury is a powerful oxidant with partial free radical character. It depletes antioxidants, especially glutathione, the core intracellular protectant.

Glutathione is especially important in liver detoxification.

The problem is that mercury binds tightly to glutathione peroxidases and other selenium-dependent enzymes, therefore endangering the whole antioxidant and detoxification system.

Mercury has also been shown to induce autoantibodies to myelin and poison the mitochondria. In fact, mercury is the most potent toxin known, and it inhibits every enzyme system and virtually every known pathway in the body.

Mercury was introduced into vaccines in the 1930s, which is approximately when the first case of autism was recorded

. Between 1970 and 1990, autism incidents doubled from 1 in 2000 to 1 in 1000 coinciding with the rise of DPT vaccines packed in thimerosal. In the late 1980s and early 1990s, two new thimerosal vaccines, the Haemophilus influenza type B vaccine and hepatitis B were added to the schedule. Perhaps coincidentally this was about the time the sharp increase in autism began. Some vaccines also contain aluminum which could compound mercury’s toxicity.

New studies established thimerosal mercury link with cell killing.

A study published in 2002 culture thimerosal with human T cells. They found that the ethyl mercury specifically caused apoptosis or cell death. The cells became depleted with glutathione. The mitochondria became decompensated, and the cells died. The exposure levels at which the thimerosal killed these human immune cells were low and well within the ranges likely attained in vaccinated children.

The autistic child may be a casualty of the toxicity of modern society. I feel that transplacental mercury transfer from the mother is the main initiating cause. This is also compounded by over-vaccination leading to multisystemic abnormalities of the brain, the gut, the immune system and a subsequent autoimmune reaction threatening the whole body. The key to treatment is to detoxify your body, to clean house, to eliminate toxins, microbes, and repair.Remember I feel that mercury infections and electrosmog cause autism and all cerebral diseases.Please read Part 2 and Part 3 of Autism to learn more.

If you need further information on autism and think your child should be investigated, please call my office for an appointment. We have an extensive autism protocol with evaluation and treatment plans.

I MEASURE AUTOANTIBODIES FOR MERCURY, FOODS AND LEVELS IN THE BRAIN.

CYTOKINES ARE MEASURED. MITOCHONDRIA FUNCTION, GLUTATHIONE, HEAVY METALS, GLUTEN AND CROSS REACTING FOODS . I LOOK FOR CANDIDA, LYME OR ITS COINFECTIONS

AFTER TESTING A PERSONALIZED PROGRAM TO ADDRESS ALL THE UNDERLYING FACTORS IS STARTED . I USE IV THERAPY, IV OZONE , HYPERBARIC OXYGEN , PEMF, PHOTON THERAPY AND MICROCURRENT AND CHELATION OF METALS

Oxytocin is also used.

PLEASE READ AUTISM PART 2 and 3

Best in health,

Dean Silver, M.D.