Intravenous IV Magnesium In The Myers Cocktail

Intravenous IV Magnesium In The Myers Cocktail


Magnesium is critical for every tissue in the body. I have been studying magnesium and have been using it in my practice for almost 30 years. Further research has lead me to several studies that demonstrated the ability of magnesium to relax blood vessels.

Magnesium is critical for the health of not only the blood vessel, but also every tissue and organ in the body.

Deficiencies of these essential elements are linked to many maladies.

These include:

  • Heart disease.
  • Strokes.
  • Atherosclerosis.
  • Abnormal kidney function.
  • Muscle weakness.
  • Diabetes.
  • Insulin resistance.
  • Metabolic syndrome.
  • Inflammation.
  • Neurodegenerative disease.
  • Impaired lung function.
  • Cancer.
  • Immune disorders.


Unfortunately, most doctors no very little about magnesium and they rarely order tests to determine if a patient is magnesium deficient.  The problem is that they usually order a blood test which looks at blood levels and not tissue levels.  The problem here is that because 99% of the magnesium in our bodies is located within the cell.  That is only 1% of the blood.


Inflammation is now known to cause severe side-effects in the body.  These include cancer, heart disease, and neurological diseases.  In fact, every organ is involved.

For example, when viruses invade the body, the immune system is activated.  It releases massive amounts of free radicals in an attempt to kill the virus.  If the virus is not killed rapidly, thus allowing the immune system to return to normal, these products of oxidation begin to destroy the body’s surrounding tissue.

The same occurs with anything exposure to any of the toxins including industrial pollutants, toxic heavy metals, pesticides, herbicides,  excess iron, high levels of glutamate, and oxidized fats.

The real reason cancer takes so long to develop is that, in most cases, it results from chronic inflammation over years.  Over many years, released free radicals damage the DNA along with other factors resulting in activation of cancer genes and cancer prompting cell signaling processes.

Recent studies have shown that magnesium stops inflammation by inhibiting calcium triggered inflammation pathways in cells.  In one experiment, researches used a substance known to induce severe inflammation called a lipopolysaccharide.  The researches found that if animals were given magnesium prior to the exposure to the inflammatory chemical, the inflammation was drastically reduced.

Other studies have shown that calcium itself is a major trigger for inflammation, which should cause concern for almost everyone, especially the woman who is taking calcium supplements and drinking milk to avoid osteoporosis.  Magnesium counteracts this negative effect of calcium which means that if you take calcium supplements you should take magnesium as well.

Animal studies have shown that if magnesium deficiency gets worse, the release of pro-inflammatory chemicals called cytokines increases dramatically.

So, as your body becomes more inflamed with age, your risk increases for developing inflammation related diseases such as hypertension, heart disease, cancer, neurodegeneration, and strokes.  Unfortunately, magnesium deficiency is very common, especially in those who eat a Western diet high in red meat, fat, and sugars, and low in fresh fruit and vegetables.  It is also known that carbonated sodas deplete the body of magnesium.

As much as 75% of Americans eat diets deficient magnesium and two-thirds of these people are significantly deficient.


Magnesium plays a major role in protecting all of the blood vessels in the body, especially the heart.  A growing number of studies show that magnesium plays an important role in preventing heart failure, heart attacks, abnormal heart rhythm, and heart muscle degeneration.

Studies have shown that low magnesium intake, especially if over an extended period of time can cause significant damage to the heart and even cause heart failure.  There is convincing evidence to suggest that low magnesium triggers a progressive inflammation of the heart with infiltration of inflammatory white cells into the heart muscle itself.

Low magnesium also causes an elevation in a number of inflammatory, cell signaling molecules called cytokines, such as interleukin-6 (IL-6) and TNF alpha.  Both of these substances are associated with a poor prognosis in cases of heart attacks or congestive heart failure.

Other studies have shown that a level of another inflammatory substance called substance P rises in heart muscle and blood vessels with low magnesium, and that substance P stimulates histamine release, which worsens inflammation.  In animal models of magnesium deficiency, as the deficiency worsens the animal develops progressive heart damage. This accompanied by a rise in the inflammatory cytokines levels both in the heart and within the endothelium which is the lining of the blood vessel wall.   A high level of substance P are common in human hear disease cases.

Another study also demonstrated that substance P came from the spinal cord ganglion supplying the nerves to the heart, and glutamate which is an excitatory neurotransmitter caused it to be released.

Once substance P entered the heart muscle and blood, it triggered intense inflammation of the heart and caused a depletion of essential glutathione one of the cells most important antioxidant systems.  The study also found that after magnesium had been at low levels for two weeks, one inflammatory marker PGE2 rose 300% higher than normal.  Either blocking the glutamate receptors or raising magnesium levels quickly lowered the PGE2 to normal levels.

These results confirm that inflammation of the heart muscle plays a major role in congestive heart failure, and that reducing the inflammation could dramatically improves heart function.  Studies have shown that the entire nerve system of the heart is controlled by glutamate-type receptors and that when these receptors are over stimulated they can cause the heart to beat abnormally a condition called an arrhythmia.  The heart muscle itself contains numerous glutamate receptors.  When they are over stimulated, they can lead to congestive heart failure caused by excitotoxicity.


Excitotoxins have a very important effect on the heart when you realize that all of the processed foods are absolutely filled with additives such as monosodium glutamate (MSG), Aspartame, or hydrolyzed vegetable protein just to mention a few.  Research has found that when animals are purposely made deficient in magnesium and then frightened or stress is introduced, most will die.  But if magnesium is added back into their diet, scaring them will not kill them.

The mechanism for death appears to be related to the fact that one of magnesium’s principal jobs is to control one of the glutamate receptors called NMDA, which is located all over the body.  When magnesium is low these receptors become oversensitive.  This is why MSG associated headaches, diarrhea, flushing, and rapid heartbeats come from eating food high in MSG.

This is sometimes called the Chinese restaurant syndrome. It is important to understand that high glutamate levels can cause widespread damage in your body without your knowledge.  The typical United States diet is low in magnesium and has high amounts of excitotoxic additives.


Low magnesium levels also cause a drastic in the release of fight or flight hormones such as adrenaline into the blood stream.  These hormones cause heart disease by raising blood pressure that strains an already weakened heart and leads to congestive heart failure.  These hormones also damage the brain and lead to degenerative diseases such as Parkinson’s, Alzheimer’s, multiple sclerosis, and ALS. This is discussed elsewhere in detail on this site.

When adrenaline levels are elevated, blood pressure rises and the heart becomes more irritable which can lead to an arrhythmia and possible sudden death.  Studies have shown that magnesium significantly reduces the release of a excessive adrenaline, also called norepinephrine.

The first study suggesting a link to magnesium in drinking water and the risk of death from a heart attack came from Japan in 1957.  A later study from Finland in 2004, confirmed the Japanese data, showing that the higher the magnesium level the more productive it was.

Another recent study found that mineral water with the highest magnesium content lowered blood pressure if it also contained calcium.  However, calcium alone can have numerous harmful affects on the body.  Magnesium also reduces blood clots by slightly increasing the bleeding time, but doesn’t have any negative effect on normal blood clotting.

The ability of magnesium to improve the function endothelia (the cells lining the arteries) and to reduce excessive clotting provides major protection against heart attack and stroke.  Magnesium is essential for normal heart function and plays a role in preventing heart irritability.  It is critical for heart muscle energy production and for preventing heart inflammation.


A study of healthy postmenopausal women aged 47 to 78 found that when the subjects were placed on a magnesium poor diet for 6 months they developed more heart irritability than normal.  The author of this study noted that many women regularly eat a diet that is deficient of magnesium as the women in the study.  American women have diets that generally do not meet the RDA requirements of magnesium which are 320 mg a day even more for those classified as deficient.

If healthy women are developing abnormal heart irritability and arrhythmias on a low magnesium diet, then those with preexisting heart disease or those that drink alcohol and caffeine are even at a greater risk.

The study also explains why mortality following a heart attack is much higher when magnesium levels are low, and why magnesium to heart attack patients reduces mortality.

People who have not had a myocardial infarction and die of sudden death, unexpected heart failure have also been found to have lower levels of magnesium in the heart muscle than levels found in a healthy heart.  This study was done over 30 years ago so one can expect magnesium deficiency to be far greater today with the public’s dependence on junk food, carbonated sodas which all deplete magnesium.


Sudden cardiac deaths account for more than 50% of all heart attacks, with between 200,000 and 500,000 fatalities annually. One of the largest and best studies ever conducted on sudden cardiac death and magnesium used was from the Nurses Heath Study, which contained data of more than 112,000 female nurses age 30 to 55.  Researchers selected out 505 women and followed for 26 years to see if there was a relationship between magnesium levels and sudden cardiac death.

What they found was that women with the lowest dietary magnesium intake and the lowest blood magnesium were significantly more likely to die of sudden death than those who had the highest magnesium levels and intake.

Magnesium has been shown to protect the cardiovascular system in many ways:

  • Improving vascular tone of the blood vessel.
  • Regulating metabolism of lipids.
  • Playing a vital role in endothelial function.
  • Reduces inflammation.
  • Lowers blood pressure.
  • Inhibits blood clotting.


In one study magnesium was shown to inhibit the deposits of lipids in the walls of the aorta that is an inhibited plague formation, a major factor in atherosclerosis.

In the bloodstream, about 60% of the magnesium comes in the form of a free ion and the rest is bound, mostly to a protein called albumin.  Studies are doing serum magnesium levels which do not reflect the storage of magnesium, since most magnesium is inside the cell.

In another study, it showed a relationship between the magnesium and blood lipids such as cholesterol.  They found that the levels of blood ionized magnesium but not total magnesium correlated closely with the levels of LDL cholesterol and total cholesterol.

Because magnesium is a powerful anti-inflammatory element, it would be expected to help prevent cholesterol from oxidizing.  This may be why it reduces atherosclerotic plague in experimental animals.

Another study looked at the amount of lipids deposited in the heart valve of the left side of the heart and aorta.  The study looked at lipid deposits, as well as calcium deposits in the kidneys.  They found that feeding the animal a high magnesium diet prevented kidney damage, removed the calcium from the kidney and heart, and prevented lipid deposits in the heart and valve.

The important observation here is that magnesium protected the heart, kidneys, and blood vessels even when the cholesterol was extremely high.  This study also showed that one must have the adequate intake of calcium somewhere around 600 per day.


The earliest stage of atherosclerosis is called endothelial dysfunction and is described elsewhere on this site.  The endothelium is a layer of cells that line the arteries.  They operate the opening and closing of the blood vessel wall thus regulating blood flow and more importantly preventing fats from entering the wall of the blood vessel.

In this first stage of atherosclerosis, oxide lipids enter the vessel wall. Higher magnesium intake has been shown to be reverse insulin resistance.

Higher magnesium levels were also found to have a lower marker of cardiac CRP, as well as E-selectin, a molecule that indicates endothelial dysfunction.  This means that taking in more magnesium can possibly stop diabetes before it starts.  In several studies the greatest effect on blood vessel inflammation came from green leafy vegetables and nuts.

Interestingly, only green leafy vegetables lowered the elevated interleukin-6, which are closely associated with heart failure.  There was another study also found dramatic improvement in endothelial function with magnesium supplementation in patients with coronary heart disease.


I use magnesium in the Myers cocktail and other intravenous drips.  I feel that magnesium is critical for the human body.  It is essential for proper function of the heart and cardiovascular system, the muscles, nervous system, and every other tissue and organ in the body.  Magnesium helps regulate all body functions and is a needed cofactor in many biochemical reactions.  As you can see, I use Myers cocktail magnesium in the majority of my patients.

If you need further information on intravenous magnesium, intravenous vitamin C, Myers  cocktail, Plaquex, chelation, and ozone please call our office for an appointment.

Best in health,

Dean R. Silver, M.D.

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